{"id":454,"date":"2026-05-29T17:53:38","date_gmt":"2026-05-29T16:53:38","guid":{"rendered":"https:\/\/hcp.cingal.com\/?page_id=454"},"modified":"2026-08-11T17:24:28","modified_gmt":"2026-08-11T16:24:28","slug":"clinical-papers-publications","status":"publish","type":"page","link":"https:\/\/hcp.cingal.com\/es\/clinical-evidence\/clinical-papers-publications\/","title":{"rendered":"Art\u00edculos y publicaciones cl\u00ednicas"},"content":{"rendered":"<nav class=\"sub-navigation-block acf-block section-padding-3xl sub-navigation-block--sticky align wp-block-acf-sub-navigation\" data-block=\"sub-navigation\" data-block-title=\"Sub Navigation Row\" data-sticky=\"true\" aria-label=\"Navegaci\u00f3n de secci\u00f3n de p\u00e1gina\" data-detect-dark-bg=\"true\">\n\t<div class=\"sub-nav__select-wrap\">\n\t\t<select class=\"sub-nav__select\" aria-label=\"Navegaci\u00f3n de secci\u00f3n de p\u00e1gina\">\n\t\t\t\t\t\t\t\t\t\t\t<option 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seguridad\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"sub-nav__item\">\n\t\t\t\t\t\t\t\t<a href=\"https:\/\/hcp.cingal.com\/es\/clinical-evidence\/clinical-papers-publications\/\"\n\t\t\t\t\t\t\t\t   class=\"sub-nav__link\"\n\t\t\t\t\t\t\t\t   \t\t\t\t\t\t\t\t   >\n\t\t\t\t\t\t\t\t\tArt\u00edculos y publicaciones cl\u00ednicas\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/nav>\n\n\n\n<section class=\"hero hero-animate acf-block section-padding-3xl hero-content-left has-background-image has-overlay has-overlay--gradient hero-text-light has-dark-bg align wp-block-acf-hero has-background has-blue-background-color\" data-block=\"hero\" data-block-title=\"Hero Section\" data-section-dark-bg=\"true\" data-detect-dark-bg=\"true\">\n          <div class=\"hero__image-wrapper\">\n          <img width=\"1200\" height=\"500\" 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https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/clinical-papers-female-doctor-e1785950670226-18x8.webp 18w\" \/>                    <div class=\"hero__overlay\"><\/div>\n               <\/div>\n     \n     <div class=\"container\">\n                    <!-- Full width content (existing layout) -->\n          <div class=\"hero-content\">\n               <h1>Art\u00edculos y publicaciones cl\u00ednicas<\/h1>\n\n<div class=\"hero-description\"><p>Publicaciones evaluadas por expertos seleccionadas, enlaces al registro ClinicalTrials.gov y lista de referencias completa para su uso en la toma de decisiones cl\u00ednicas<\/p>\n<\/div>\n\n          <\/div>\n\n                         <\/div>\n<\/section>\n\n\n\n\n\n<section class=\"publications-accordion acf-block section-padding-3xl align wp-block-acf-publications-accordion\" id=\"publications-accordion-6a98709a3b4e9\" data-detect-dark-bg=\"true\" data-block=\"publications-accordion\" data-block-title=\"Publications Accordion\">\n\t<div class=\"container\">\n\t\t\t\t\t<h2 class=\"publications-accordion__heading section-title\">Publicaciones revisadas por pares<\/h2>\n\t\t\n\t\t\t\t\t<div class=\"publications-accordion__items\">\n\t\t\t\t<!-- Live Region for Screen Reader Announcements -->\n\t\t\t\t<div class=\"screen-reader-text\" role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/div>\n\n\t\t\t\t\t\t\t\t<div class=\"publications-accordion__item\" data-accordion-item>\n\t\t\t\t\t<button\n\t\t\t\t\t\ttype=\"button\"\n\t\t\t\t\t\tclass=\"publications-accordion__header\"\n\t\t\t\t\t\tid=\"publications-accordion-6a98709a3b4e9-btn-0\"\n\t\t\t\t\t\taria-expanded=\"true\"\n\t\t\t\t\t\taria-controls=\"publications-accordion-6a98709a3b4e9-panel-0\"\n\t\t\t\t\t>\n\t\t\t\t\t\t<span class=\"publications-accordion__header-text\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"publications-accordion__badge\">Ensayo cl\u00ednico de fase III<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"publications-accordion__title h5\">Ensayo aleatorizado y controlado con placebo de Cingal en la osteoartritis de rodilla<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"publications-accordion__meta\">Hangody L, y col. \u00b7 Ensayo multic\u00e9ntrico aleatorizado, doble ciego, controlado con placebo \u00b7 n=368<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"publications-accordion__toggle\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t<svg class=\"publications-accordion__toggle-icon\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" focusable=\"false\">\n\t\t\t\t\t\t\t\t<path d=\"M6 9L12 15L18 9\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t\t\t\t\t\t<\/svg>\n\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/button>\n\n\t\t\t\t\t<div\n\t\t\t\t\t\tclass=\"publications-accordion__panel\"\n\t\t\t\t\t\tid=\"publications-accordion-6a98709a3b4e9-panel-0\"\n\t\t\t\t\t\trole=\"region\"\n\t\t\t\t\t\taria-labelledby=\"publications-accordion-6a98709a3b4e9-btn-0\"\n\t\t\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t<div class=\"publications-accordion__card has-nested-bg\" data-detect-dark-bg=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"publications-accordion__label\">Full Title<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"publications-accordion__full-title\">Inyecci\u00f3n intraarticular de hialuronato s\u00f3dico reticulado combinado con hexacetonida de triamcinolona (Cingal) para el alivio sintom\u00e1tico de la osteoartritis de rodilla: ensayo cl\u00ednico multic\u00e9ntrico, aleatorizado, doble ciego y controlado con placebo.<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"publications-accordion__authors\">Laszlo Hangody, Robert Szody, Piotr Lukasik, Wojciech Zgadzaj, Endre L\u00e9n\u00e1rt, Eva Dokoupilova, Daniela Bichovsk, Agnes Berta, Gabor Vasarhelyi, Andrea Ficzere, Gy\u00f6rgy Hangody, Gary Stevens, Miklos Szendroi<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"publications-accordion__label\">Key Takeaways<\/p>\n\t\t\t\t\t\t\t\t<div class=\"publications-accordion__takeaways wysiwyg-editor-content\">\n\t\t\t\t\t\t\t\t\t<ul>\n<li><strong>Estudio multic\u00e9ntrico aleatorizado, doble ciego, controlado con placebo<\/strong> Evaluaci\u00f3n de Cingal (hialuronato s\u00f3dico reticulado + hexacetonida de triamcinolona) para la osteoartritis de rodilla<\/li>\n<li><strong>Pacientes (n=368)<\/strong> recibieron o bien Cingal, \u00e1cido hialur\u00f3nico solo o un placebo de soluci\u00f3n salina.<\/li>\n<li><strong>El grupo Cingal mostr\u00f3 un alivio del dolor significativamente mayor<\/strong> en los puntos temporales iniciales (semanas 1-3) en comparaci\u00f3n con ambos comparadores.<\/li>\n<li><strong>Mejora sostenida en las puntuaciones WOMAC<\/strong> hasta la semana 26, especialmente en los \u00e1mbitos del dolor y la funci\u00f3n.<\/li>\n<li><strong>No se informaron eventos adversos graves;<\/strong> perfil de seguridad comparable en todos los grupos.<\/li>\n<li><strong>Conclusi\u00f3n:<\/strong> Cingal proporciona un alivio r\u00e1pido y duradero de los s\u00edntomas de la artrosis de rodilla, al combinar los beneficios del \u00e1cido hialur\u00f3nico y los corticosteroides en una sola inyecci\u00f3n.<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"publications-accordion__cta\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6042027\/pdf\/10.1177_1947603517703732.pdf\" target=\"_blank\" class=\"btn btn-primary publications-accordion__cta-link\" rel=\"noopener noreferrer\">Ver en PubMed <span class=\"screen-reader-text\">(opens in a new tab)<\/span><\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<div class=\"publications-accordion__item\" data-accordion-item>\n\t\t\t\t\t<button\n\t\t\t\t\t\ttype=\"button\"\n\t\t\t\t\t\tclass=\"publications-accordion__header\"\n\t\t\t\t\t\tid=\"publications-accordion-6a98709a3b4e9-btn-1\"\n\t\t\t\t\t\taria-expanded=\"false\"\n\t\t\t\t\t\taria-controls=\"publications-accordion-6a98709a3b4e9-panel-1\"\n\t\t\t\t\t>\n\t\t\t\t\t\t<span class=\"publications-accordion__header-text\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"publications-accordion__badge\">An\u00e1lisis socioecon\u00f3mico de la salud<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"publications-accordion__title h5\">Relaci\u00f3n coste-utilidad del tratamiento Cingal de una sola inyecci\u00f3n frente a un r\u00e9gimen de dos inyecciones<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"publications-accordion__meta\">Belzile EL, et al. \u00b7 An\u00e1lisis de coste-utilidad \u00b7 $50 000\/QALY como umbral de disposici\u00f3n a pagar<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"publications-accordion__toggle\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t<svg class=\"publications-accordion__toggle-icon\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" focusable=\"false\">\n\t\t\t\t\t\t\t\t<path d=\"M6 9L12 15L18 9\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t\t\t\t\t\t<\/svg>\n\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/button>\n\n\t\t\t\t\t<div\n\t\t\t\t\t\tclass=\"publications-accordion__panel\"\n\t\t\t\t\t\tid=\"publications-accordion-6a98709a3b4e9-panel-1\"\n\t\t\t\t\t\trole=\"region\"\n\t\t\t\t\t\taria-labelledby=\"publications-accordion-6a98709a3b4e9-btn-1\"\n\t\t\t\t\t\thidden\t\t\t\t\t>\n\t\t\t\t\t\t<div class=\"publications-accordion__card has-nested-bg\" data-detect-dark-bg=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"publications-accordion__label\">Full Title<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"publications-accordion__full-title\">Coste-utilidad de una formulaci\u00f3n combinada de corticoide y \u00e1cido hialur\u00f3nico en inyecci\u00f3n \u00fanica frente a un r\u00e9gimen de dos inyecciones de corticoide y \u00e1cido hialur\u00f3nico secuenciales<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"publications-accordion__authors\">Etienne L. Belzile, Robert T. Deakon, Christopher Vannabouathong, Mohit Bhandari, Martin Lamontagne y Robert McCormack<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"publications-accordion__label\">Key Takeaways<\/p>\n\t\t\t\t\t\t\t\t<div class=\"publications-accordion__takeaways wysiwyg-editor-content\">\n\t\t\t\t\t\t\t\t\t<ul>\n<li><strong>An\u00e1lisis de coste-utilidad que compara<\/strong> una formulaci\u00f3n de una sola inyecci\u00f3n de corticosteroide + \u00e1cido hialur\u00f3nico (Cingal) frente a un r\u00e9gimen de dos inyecciones secuenciales de corticosteroide y \u00e1cido hialur\u00f3nico.<\/li>\n<li><strong>Se ha comprobado que el tratamiento Cingal de inyecci\u00f3n \u00fanica resulta rentable<\/strong>, suponiendo un umbral de disposici\u00f3n a pagar de $50 000 por a\u00f1o de vida ajustado por calidad (AVAC) ganado.<\/li>\n<li><strong>Los modelos econ\u00f3micos mostraron que los costes generales del tratamiento eran m\u00e1s bajos<\/strong> y un alivio de los s\u00edntomas sostenido y comparable con el enfoque de una sola inyecci\u00f3n.<\/li>\n<li><strong>Una gesti\u00f3n m\u00e1s sencilla y una menor carga para los pacientes<\/strong> hacen que el Cingal sea una opci\u00f3n recomendable en la pr\u00e1ctica cl\u00ednica.<\/li>\n<li><strong>Conclusi\u00f3n:<\/strong> Cingal ofrece una alternativa rentable y eficaz a los tratamientos con inyecciones m\u00faltiples para el control de los s\u00edntomas de la artrosis de rodilla.<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"publications-accordion__cta\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1179544117712993\" target=\"_blank\" class=\"btn btn-primary publications-accordion__cta-link\" rel=\"noopener noreferrer\">Ver publicaci\u00f3n <span class=\"screen-reader-text\">(opens in a new tab)<\/span><\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<div class=\"publications-accordion__item\" data-accordion-item>\n\t\t\t\t\t<button\n\t\t\t\t\t\ttype=\"button\"\n\t\t\t\t\t\tclass=\"publications-accordion__header\"\n\t\t\t\t\t\tid=\"publications-accordion-6a98709a3b4e9-btn-2\"\n\t\t\t\t\t\taria-expanded=\"false\"\n\t\t\t\t\t\taria-controls=\"publications-accordion-6a98709a3b4e9-panel-2\"\n\t\t\t\t\t>\n\t\t\t\t\t\t<span class=\"publications-accordion__header-text\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"publications-accordion__badge\">Estudio in vitro<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"publications-accordion__title h5\">Efecto condroprotector de la combinaci\u00f3n de \u00e1cido hialur\u00f3nico con un glucocorticoide<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"publications-accordion__meta\">Bauer C, et al. \u00b7 Estudio in vitro \u00b7 Condrocitos humanos con osteoartritis tratados con citocinas<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"publications-accordion__toggle\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t<svg class=\"publications-accordion__toggle-icon\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" focusable=\"false\">\n\t\t\t\t\t\t\t\t<path d=\"M6 9L12 15L18 9\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t\t\t\t\t\t<\/svg>\n\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/button>\n\n\t\t\t\t\t<div\n\t\t\t\t\t\tclass=\"publications-accordion__panel\"\n\t\t\t\t\t\tid=\"publications-accordion-6a98709a3b4e9-panel-2\"\n\t\t\t\t\t\trole=\"region\"\n\t\t\t\t\t\taria-labelledby=\"publications-accordion-6a98709a3b4e9-btn-2\"\n\t\t\t\t\t\thidden\t\t\t\t\t>\n\t\t\t\t\t\t<div class=\"publications-accordion__card has-nested-bg\" data-detect-dark-bg=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"publications-accordion__label\">Full Title<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"publications-accordion__full-title\">Mayor efecto condroprotector de la combinaci\u00f3n de \u00e1cido hialur\u00f3nico con un glucocorticoide en comparaci\u00f3n con la administraci\u00f3n separada en condrocitos osteoartr\u00edticos tratados con citocinas en un cultivo 2D<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"publications-accordion__authors\">Christoph Bauer, Lukas B. Moser, Vivek Jeyakumar, Eugenia Niculescu-Morzsa, Daniela Kern, Stefan Nehrer<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"publications-accordion__label\">Key Takeaways<\/p>\n\t\t\t\t\t\t\t\t<div class=\"publications-accordion__takeaways wysiwyg-editor-content\">\n\t\t\t\t\t\t\t\t\t<ul>\n<li><strong>Estudio in vitro<\/strong> utilizando condrocitos humanos con osteoartritis tratados con citocinas inflamatorias (IL-1\u03b2 e IL-17) para simular las condiciones de la OA.<\/li>\n<li>Comparaci\u00f3n de los efectos de <strong>glucocorticoide (hexacetonida de triamcinolona), \u00e1cido hialur\u00f3nico (AH) y su combinaci\u00f3n<\/strong> sobre la salud de los condrocitos y la inflamaci\u00f3n.<\/li>\n<li><strong>El tratamiento combinado con GC\/HA mejor\u00f3 la actividad metab\u00f3lica<\/strong>, redujo la expresi\u00f3n de los genes catab\u00f3licos y disminuy\u00f3 la liberaci\u00f3n de TNF-\u03b1 de forma m\u00e1s eficaz que cualquiera de los dos agentes por separado.<\/li>\n<li><strong>El HA atenu\u00f3 los efectos celulares negativos de los glucocorticoides<\/strong>, tales como la polimerizaci\u00f3n de actina reducida y el aumento del estr\u00e9s oxidativo.<\/li>\n<li><strong>Conclusi\u00f3n:<\/strong> La coadministraci\u00f3n de AH y GC ofrece efectos antiinflamatorios y condroprotectores superiores en comparaci\u00f3n con la administraci\u00f3n por separado, lo que respalda la justificaci\u00f3n de las terapias combinadas en el manejo de la OA.<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"publications-accordion__cta\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9313299\/pdf\/biomedicines-10-01733.pdf\" target=\"_blank\" class=\"btn btn-primary publications-accordion__cta-link\" rel=\"noopener noreferrer\">Ver en PubMed <span class=\"screen-reader-text\">(opens in a new tab)<\/span><\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":441,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-454","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cingal Clinical Publications: Peer-Reviewed Papers<\/title>\n<meta name=\"description\" content=\"Clinical publications, a curated list of peer-reviewed papers, ClinicalTrials.gov links and full references to support prescriber review.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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