{"id":451,"date":"2026-04-20T20:40:35","date_gmt":"2026-04-20T19:40:35","guid":{"rendered":"https:\/\/hcp.cingal.com\/?page_id=451"},"modified":"2026-09-01T12:27:01","modified_gmt":"2026-09-01T11:27:01","slug":"estudios-de-ensayos","status":"publish","type":"page","link":"https:\/\/hcp.cingal.com\/es\/clinical-evidence\/trials-studies\/","title":{"rendered":"Ensayos cl\u00ednicos y estudios"},"content":{"rendered":"<nav class=\"sub-navigation-block acf-block section-padding-3xl sub-navigation-block--sticky align wp-block-acf-sub-navigation\" data-block=\"sub-navigation\" data-block-title=\"Sub Navigation Row\" data-sticky=\"true\" aria-label=\"Navegaci\u00f3n de secci\u00f3n de p\u00e1gina\" data-detect-dark-bg=\"true\">\n\t<div class=\"sub-nav__select-wrap\">\n\t\t<select class=\"sub-nav__select\" aria-label=\"Navegaci\u00f3n de secci\u00f3n de p\u00e1gina\">\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"https:\/\/hcp.cingal.com\/es\/clinical-evidence\/trials-studies\/\" 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seguridad\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"sub-nav__item\">\n\t\t\t\t\t\t\t\t<a href=\"https:\/\/hcp.cingal.com\/es\/clinical-evidence\/clinical-papers-publications\/\"\n\t\t\t\t\t\t\t\t   class=\"sub-nav__link\"\n\t\t\t\t\t\t\t\t   \t\t\t\t\t\t\t\t   >\n\t\t\t\t\t\t\t\t\tArt\u00edculos y publicaciones cl\u00ednicas\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/nav>\n\n\n\n<section class=\"hero hero-animate acf-block section-padding-3xl hero-content-left hero-has-table has-default-bg has-dark-bg align wp-block-acf-hero\" data-block=\"hero\" data-block-title=\"Hero Section\" data-detect-dark-bg=\"true\">\n     \n     <div class=\"container\">\n                    <!-- Content left\/right with side-aligned image -->\n          <div class=\"row hero-wrapper\">\n               \n               <div class=\"col-6 col-sm-12 hero-content\">\n                    <h1>Amplia evidencia en la osteoartritis de rodilla<\/h1>\n\n<div class=\"hero-description\"><p>La base cl\u00ednica de Cingal se sustenta en m\u00faltiples ensayos cl\u00ednicos aleatorizados y controlados de fase III realizados en pacientes con osteoartritis de rodilla.<\/p>\n<\/div>\n\n<div class=\"hero-ctas\">\n     <a href=\"#outcome-data\" class=\"btn btn-light hero-primary-cta\">Ir a los datos de resultados<\/a><\/div>\n               <\/div>\n\n                              <!-- Content on left, data table on right -->\n               <div class=\"col-6 col-sm-12 hero-table-col\">\n                    <div class=\"hero-table has-nested-bg\">\n                                                  <p class=\"hero-table__title\">Ensayo pivotal de un vistazo: Estudio 13-01<\/p>\n                                                  <table class=\"hero-table__table\">\n                              <tbody>\n                                                                      <tr class=\"hero-table__row\">\n                                        <th class=\"hero-table__label\" scope=\"row\">Dise\u00f1o<\/th>\n                                        <td class=\"hero-table__value\">Fase III aleatorizada, doble ciego y multic\u00e9ntrica<\/td>\n                                   <\/tr>\n                                                                      <tr class=\"hero-table__row\">\n                                        <th class=\"hero-table__label\" scope=\"row\">Pacientes<\/th>\n                                        <td class=\"hero-table__value\">368<\/td>\n                                   <\/tr>\n                                                                      <tr class=\"hero-table__row\">\n                                        <th class=\"hero-table__label\" scope=\"row\">Poblaci\u00f3n<\/th>\n                                        <td class=\"hero-table__value\">Artrosis de rodilla, grados KL I\u2013III<\/td>\n                                   <\/tr>\n                                                                      <tr class=\"hero-table__row\">\n                                        <th class=\"hero-table__label\" scope=\"row\">Seguimiento<\/th>\n                                        <td class=\"hero-table__value\">26 semanas<\/td>\n                                   <\/tr>\n                                                                      <tr class=\"hero-table__row\">\n                                        <th class=\"hero-table__label\" scope=\"row\">Punto final primario<\/th>\n                                        <td class=\"hero-table__value\">puntuaci\u00f3n de dolor WOMAC<\/td>\n                                   <\/tr>\n                                                                      <tr class=\"hero-table__row\">\n                                        <th class=\"hero-table__label\" scope=\"row\">Comparadores<\/th>\n                                        <td class=\"hero-table__value\">\u00c1cido hialur\u00f3nico solo \u00b7 Soluci\u00f3n salina<\/td>\n                                   <\/tr>\n                                                                      <tr class=\"hero-table__row\">\n                                        <th class=\"hero-table__label\" scope=\"row\">Referencia<\/th>\n                                        <td class=\"hero-table__value\">Hangody y col., Cartilage 2018<\/td>\n                                   <\/tr>\n                                                                 <\/tbody>\n                         <\/table>\n                    <\/div>\n               <\/div>\n                         <\/div>\n               <\/div>\n<\/section>\n\n\n\n<section class=\"icon-text-box-grid-section layout-side-by-side media-size-icon acf-block section-padding-3xl align wp-block-acf-icon-text-box-grid has-background has-blue-light-background-color\" data-block=\"icon-text-box-grid\" data-block-title=\"Icon &amp; Text Box Grid\" data-detect-dark-bg=\"true\">\n    <div class=\"row icon-text-box-grid container\">\n                    <!-- Side-by-side layouts: Heading left, icon grid or icon list right -->\n                            <div class=\"col-5 col-md-12 section-header section-header--left\">\n                                            <h2 class=\"section-title\">Tres ensayos cl\u00ednicos de fase III<\/h2>\n                    \n                    \n                    \n                                    <\/div>\n            \n                            <div class=\"col-7 col-md-12 icon-grid-container\">\n                    <div class=\"row icon-grid-inner\">\n                            <div class=\"col-6 col-md-6 col-sm-12\">\n                \n                    <h3 class=\"box-title h5\">Dise\u00f1o del estudio y comparadores<\/h3>\n        \n                    <div class=\"box-description\"><ul>\n<li>Ensayos de fase III aleatorizados, doble ciego y multic\u00e9ntricos<\/li>\n<li>Comparaci\u00f3n de Cingal con tres comparadores activos y un placebo:\n<ul>\n<li>frente al \u00e1cido hialur\u00f3nico solo<sup>1<\/sup><\/li>\n<li>frente a Triamcinolone Hexacetonide solo<sup>2<\/sup><\/li>\n<li>frente a soluci\u00f3n salina (control con placebo)<sup>3<\/sup><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div>\n        \n            <\/div>\n        <div class=\"col-6 col-md-6 col-sm-12\">\n                \n                    <h3 class=\"box-title h5\">Resultados demostrados<\/h3>\n        \n                    <div class=\"box-description\"><ul>\n<li><strong>Alivio r\u00e1pido del dolor<\/strong> (ya desde la primera semana)<\/li>\n<li><strong>Mejoras sostenidas<\/strong> durante 26 semanas<\/li>\n<li>Mejoras estad\u00edsticamente significativas en <strong>dolor, rigidez y funci\u00f3n<\/strong> (WOMAC)<\/li>\n<li><strong>Alivio de acci\u00f3n m\u00e1s r\u00e1pida<\/strong> en comparaci\u00f3n con el AH solo<\/li>\n<li>Superioridad frente al control con soluci\u00f3n salina <strong>at measured time points<\/strong><\/li>\n<li><strong>92%: tasa de respuesta seg\u00fan OMERACT-OARSI<\/strong> a las 26 semanas<\/li>\n<\/ul>\n<\/div>\n        \n            <\/div>\n                        <\/div>\n                <\/div>\n            \n        \n        \n            <\/div>\n<\/section>\n\n\n\n<section class=\"wp-block-acf-flexible-content-area flexible-content-area-block section-padding-3xl\" data-block=\"flexible-content-area\" data-block-title=\"Flexible Content Area\"><div class=\"flexible-content-inner container\"><div class=\"flexible-content-wrapper\">\n<section style=\"padding-bottom:var(--wp--preset--spacing--md)\" class=\"two-column-content acf-block section-padding-3xl align-items-top align wide-gap-columns wp-block-acf-two-column-content\" data-block=\"two-column-content\" data-block-title=\"Two-Column Content\" data-detect-dark-bg=\"true\">\n     <div class=\"two-column-content__container container\">\n                    <div class=\"row two-column-content__grid\">\n                              <div class=\"col-7 col-sm-12 two-column-content__column two-column-content__column--left flex-col\">\n                                        <div class=\"two-column-content__content\">\n                         <h3>Un ensayo multic\u00e9ntrico mostr\u00f3 una mejora constante en todos los resultados<\/h3>\n<p>El estudio pivotal de fase III (368 pacientes, grados I-III seg\u00fan la escala de KL) compar\u00f3 el tratamiento Cingal con soluci\u00f3n salina, \u00e1cido hialur\u00f3nico (AH) solo y terapiia t\u00e9rmica (TH) sola durante 26 semanas. Los resultados demostraron mejoras estad\u00edsticamente significativas en el dolor, la rigidez y la funci\u00f3n f\u00edsica ya desde la primera semana.<\/p>\n<p>La escala compuesta WOMAC captur\u00f3 mejoras en el dolor, la rigidez y la funci\u00f3n f\u00edsica: los tres dominios m\u00e1s relevantes para la calidad de vida de los pacientes con artrosis de rodilla.<\/p>\n                    <\/div>\n                                                       <\/div>\n               \n                              <div class=\"col-5 col-sm-12 two-column-content__column two-column-content__column--right flex-col\">\n                                        <div class=\"two-column-content__content\">\n                         <h3 class=\"h5\">Perfil del estudio: Cingal 13-01<\/h3>\n<ul>\n<li>Aleatorizado, doble ciego, controlado por placebo<\/li>\n<li>368 pacientes inscritos<\/li>\n<li>Artrosis de rodilla, grados I-III seg\u00fan la escala de Kellgren-Lawrence<\/li>\n<li>Variable principal: dolor WOMAC a las 26 semanas<\/li>\n<li>Punto final secundario: tasa de respondedores OMERACT-OARSI<\/li>\n<li>Seguimiento: 26 semanas<\/li>\n<\/ul>\n                    <\/div>\n                                                       <\/div>\n                         <\/div>\n     <\/div>\n<\/section>\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-d7854776 wp-block-group-is-layout-constrained\">\n<section style=\"padding-top:var(--wp--preset--spacing--0);padding-bottom:var(--wp--preset--spacing--0)\" class=\"statistics-row-block acf-block section-padding-3xl align wide-gap-columns wp-block-acf-statistics-row\" data-detect-dark-bg=\"true\" data-block=\"statistics-row\" data-block-title=\"Statistics Row\">\n\t<div class=\"statistics-row-container container\">\n\t\t<div class=\"statistics-row-content\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"statistics-grid animate-stagger statistics-grid--divided-rows\" data-metric-size=\"md\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"statistic-item statistic-item--row\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"statistic-metric h1\">Semana 1<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"statistic-label\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"statistic-title h6\">Alivio r\u00e1pido del dolor<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"statistic-text\"><p>Se observ\u00f3 una mejor\u00eda significativa en las puntuaciones de dolor ya en la semana 1, con un inicio del alivio m\u00e1s r\u00e1pido en comparaci\u00f3n con el \u00e1cido hialur\u00f3nico solo, una diferenciaci\u00f3n cl\u00ednicamente significativa para los pacientes que esperan el control de los s\u00edntomas.<\/p>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"statistic-item statistic-item--row\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"statistic-metric h1\">72%<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"statistic-label\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"statistic-title h6\">Mejora del dolor WOMAC<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"statistic-text\"><p>Mejora en la puntuaci\u00f3n de dolor WOMAC a las 26 semanas. WOMAC (\u00cdndice de Osteoartritis de las Universidades de Western Ontario y McMaster) es la medida de resultado validada e informada por el paciente para el dolor, la rigidez y la funci\u00f3n f\u00edsica en la osteoartritis (OA).<\/p>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"statistic-item statistic-item--row\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"statistic-metric h1\">92%<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"statistic-label\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"statistic-title h6\">Respondedores OMERACT-OARSI a las 26 semanas<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"statistic-text\"><p>OMERACT-OARSI es el criterio de respuesta validado para los ensayos cl\u00ednicos sobre la artrosis. Una tasa de respuesta de 92% a las 26 semanas demuestra tanto una respuesta duradera como una elevada relevancia cl\u00ednica a nivel del paciente.<\/p>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"statistic-item statistic-item--row\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"statistic-metric h1\">Superioridad<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"statistic-label\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"statistic-title h6\">Puntos de tiempo medidos vs. Soluci\u00f3n salina<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"statistic-text\"><p>El Cingal demostr\u00f3 su superioridad frente al grupo de control con soluci\u00f3n salina en los momentos de medici\u00f3n a lo largo del periodo de seguimiento de 26 semanas, lo que confirma una eficacia constante y sostenida superior a la del placebo.<\/p>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/section>\n<\/div>\n<\/div><\/div><\/section>\n\n\n\n<section class=\"wp-block-acf-flexible-content-area flexible-content-area-block section-padding-3xl has-gray-light-background-color has-background\" data-block=\"flexible-content-area\" data-block-title=\"Flexible Content Area\" id=\"outcome-data\"><div class=\"flexible-content-inner container\"><div class=\"flexible-content-wrapper\">\n<h2 class=\"wp-block-heading\">Gr\u00e1ficos de resultados cl\u00ednicos<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Los siguientes gr\u00e1ficos ilustran los resultados de eficacia del ensayo fundamental de Fase III (Estudio 13-01).<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9ba6dbca wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-group has-white-background-color has-background is-layout-flow wp-container-core-group-is-layout-2c7d62e0 wp-block-group-is-layout-flow\" style=\"padding-top:var(--wp--preset--spacing--md);padding-right:var(--wp--preset--spacing--md);padding-bottom:var(--wp--preset--spacing--md);padding-left:var(--wp--preset--spacing--md)\" data-detect-dark-bg=\"true\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1152\" height=\"1689\" src=\"https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/womac-pain-chart.webp\" alt=\"Line graph showing WOMAC pain score reduction over 26 weeks, with Cingal achieving approximately 60-70% reduction compared to 35-50% for other single injection products.\" class=\"wp-image-2118\" srcset=\"https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/womac-pain-chart.webp 1152w, https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/womac-pain-chart-205x300.webp 205w, https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/womac-pain-chart-698x1024.webp 698w, https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/womac-pain-chart-768x1126.webp 768w, https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/womac-pain-chart-1048x1536.webp 1048w, https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/womac-pain-chart-8x12.webp 8w\" sizes=\"(max-width: 1152px) 100vw, 1152px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-group has-white-background-color has-background is-layout-flow wp-container-core-group-is-layout-2c7d62e0 wp-block-group-is-layout-flow\" style=\"padding-top:var(--wp--preset--spacing--md);padding-right:var(--wp--preset--spacing--md);padding-bottom:var(--wp--preset--spacing--md);padding-left:var(--wp--preset--spacing--md)\" data-detect-dark-bg=\"true\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1152\" height=\"1692\" src=\"https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/omeract-oarsi-responder-rate.webp\" alt=\"Infographic showing 89% of patients responded to Cingal at Week 1 and 92% at Week 26, illustrated with human figure icons in green and blue respectively.\" class=\"wp-image-2117\" srcset=\"https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/omeract-oarsi-responder-rate.webp 1152w, https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/omeract-oarsi-responder-rate-204x300.webp 204w, https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/omeract-oarsi-responder-rate-697x1024.webp 697w, https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/omeract-oarsi-responder-rate-768x1128.webp 768w, https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/omeract-oarsi-responder-rate-1046x1536.webp 1046w, https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/omeract-oarsi-responder-rate-8x12.webp 8w\" sizes=\"(max-width: 1152px) 100vw, 1152px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-group has-white-background-color has-background is-layout-flow wp-container-core-group-is-layout-2c7d62e0 wp-block-group-is-layout-flow\" style=\"padding-top:var(--wp--preset--spacing--md);padding-right:var(--wp--preset--spacing--md);padding-bottom:var(--wp--preset--spacing--md);padding-left:var(--wp--preset--spacing--md)\" data-detect-dark-bg=\"true\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1152\" height=\"1692\" src=\"https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/pain-reduction-week1-week26.webp\" alt=\"Chart showing WOMAC pain reduction results: 59% at week 1 and 72% at week 26 for Cingal treatment, displayed with green and blue icons and arrows.\" class=\"wp-image-2116\" srcset=\"https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/pain-reduction-week1-week26.webp 1152w, https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/pain-reduction-week1-week26-204x300.webp 204w, https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/pain-reduction-week1-week26-697x1024.webp 697w, https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/pain-reduction-week1-week26-768x1128.webp 768w, https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/pain-reduction-week1-week26-1046x1536.webp 1046w, https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/pain-reduction-week1-week26-8x12.webp 8w\" sizes=\"(max-width: 1152px) 100vw, 1152px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div><\/section>\n\n\n\n\n\n\n\n\n<section class=\"references-dropdown section-padding-lg align wp-block-acf-references-dropdown\" id=\"references\" data-block=\"references-dropdown\" data-block-title=\"References Dropdown\" data-detect-dark-bg=\"true\">\n\t<div class=\"container\">\n\t\t<div class=\"references-dropdown__container has-nested-bg\">\n\t\t<button\n\t\t\ttype=\"button\"\n\t\t\tclass=\"references-dropdown__header\"\n\t\t\tid=\"references-6a96f8c206379-btn\"\n\t\t\taria-expanded=\"false\"\n\t\t\taria-controls=\"references-6a96f8c206379-panel\"\n\t\t>\n\t\t\t<span class=\"references-dropdown__header-content\">\n\t\t\t\t<img\n\t\t\t\t\tsrc=\"https:\/\/hcp.cingal.com\/wp-content\/themes\/3mw-core-child\/blocks\/references-dropdown\/icon-references.svg\"\n\t\t\t\t\tclass=\"references-dropdown__icon\"\n\t\t\t\t\twidth=\"30\"\n\t\t\t\t\theight=\"37\"\n\t\t\t\t\talt=\"\"\n\t\t\t\t\taria-hidden=\"true\"\n\t\t\t\t>\n\t\t\t\t<span class=\"references-dropdown__title\">Referencias<\/span>\n\t\t\t<\/span>\n\t\t\t<span class=\"references-dropdown__toggle\" aria-hidden=\"true\">\n\t\t\t\t<svg class=\"references-dropdown__toggle-icon references-dropdown__toggle-icon--plus\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n\t\t\t\t\t<path d=\"M12 5V19\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t\t\t\t<path d=\"M5 12H19\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t\t\t<\/svg>\n\t\t\t\t<svg class=\"references-dropdown__toggle-icon references-dropdown__toggle-icon--close\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n\t\t\t\t\t<path d=\"M18 6L6 18\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t\t\t\t<path d=\"M6 6L18 18\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t\t\t<\/svg>\n\t\t\t<\/span>\n\t\t<\/button>\n\t\t<div\n\t\t\tclass=\"references-dropdown__panel\"\n\t\t\tid=\"references-6a96f8c206379-panel\"\n\t\t\trole=\"region\"\n\t\t\taria-labelledby=\"references-6a96f8c206379-btn\"\n\t\t\thidden\t\t>\n\t\t\t<div class=\"references-dropdown__content\">\n\t\t\t\t<ol>\n<li>Hangody L. y cols. Inyecci\u00f3n intraarticular de hialuronato s\u00f3dico reticulado combinado con hexacetonida de triamcinolona (Cingal) para el alivio sintom\u00e1tico de la osteoartritis de rodilla: ensayo cl\u00ednico multic\u00e9ntrico, aleatorizado, doble ciego y controlado con placebo.<span>\u00a0<\/span><em>Cart\u00edlago.<\/em><span>\u00a0<\/span>2018 Jul;9(3):276-283. doi: 10.1177\/1947603517703732. PMID: 28535076; PMCID: PMC6042027.<span>\u00a0<\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6042027\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6042027\/<\/a><\/li>\n<li class=\"references-list__item\">Datos en el Expediente 16-02.<\/li>\n<li class=\"references-list__item\">Datos en el Archivo 19-01.<\/li>\n<li>Todas las figuras: Hangody L, et al. Inyecci\u00f3n intraarticular de hialuronato de sodio reticulado combinado con hexacetonida de triamcinolona (Cingal) para el alivio sintom\u00e1tico de la osteoartritis de rodilla: ensayo cl\u00ednico multic\u00e9ntrico, aleatorizado, doble ciego y controlado con placebo. Cartilage. Julio de 2018; 9(3):276-283. doi: 10.1177\/1947603517703732. PMID: 28535076; PMCID: PMC6042027. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6042027\" target=\"_blank\" rel=\"noopener\">pmc.ncbi.nlm.nih.gov\/articles\/PMC6042027<\/a><\/li>\n<\/ol>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":441,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-451","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cingal Clinical Trials: Phase III Design and Outcomes<\/title>\n<meta name=\"description\" content=\"Cingal&#039;s pivotal Phase III trial (n=368): 72% WOMAC pain improvement and 92% OMERACT-OARSI response at 26 weeks vs. HA, TH, and saline\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hcp.cingal.com\/es\/evidencia-clinica\/estudios-de-ensayos\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cingal Clinical Trials: Phase III Design and Outcomes\" \/>\n<meta property=\"og:description\" content=\"Cingal&#039;s pivotal Phase III trial (n=368): 72% WOMAC pain improvement and 92% OMERACT-OARSI response at 26 weeks vs. HA, TH, and saline\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hcp.cingal.com\/es\/evidencia-clinica\/estudios-de-ensayos\/\" \/>\n<meta property=\"og:site_name\" content=\"Cingal for Healthcare Professionals\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-01T11:27:01+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/hcp.cingal.com\/wp-content\/uploads\/sites\/2\/2026\/08\/womac-pain-chart.webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/hcp.cingal.com\\\/clinical-evidence\\\/trials-studies\\\/\",\"url\":\"https:\\\/\\\/hcp.cingal.com\\\/clinical-evidence\\\/trials-studies\\\/\",\"name\":\"Cingal Clinical Trials: Phase III Design and Outcomes\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/hcp.cingal.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/hcp.cingal.com\\\/clinical-evidence\\\/trials-studies\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/hcp.cingal.com\\\/clinical-evidence\\\/trials-studies\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/hcp.cingal.com\\\/wp-content\\\/uploads\\\/sites\\\/2\\\/2026\\\/08\\\/womac-pain-chart.webp\",\"datePublished\":\"2026-04-20T19:40:35+00:00\",\"dateModified\":\"2026-09-01T11:27:01+00:00\",\"description\":\"Cingal's pivotal Phase III trial (n=368): 72% WOMAC pain improvement and 92% OMERACT-OARSI response at 26 weeks vs. HA, TH, and saline\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/hcp.cingal.com\\\/clinical-evidence\\\/trials-studies\\\/#breadcrumb\"},\"inLanguage\":\"es-ES\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/hcp.cingal.com\\\/clinical-evidence\\\/trials-studies\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"es-ES\",\"@id\":\"https:\\\/\\\/hcp.cingal.com\\\/clinical-evidence\\\/trials-studies\\\/#primaryimage\",\"url\":\"https:\\\/\\\/hcp.cingal.com\\\/wp-content\\\/uploads\\\/sites\\\/2\\\/2026\\\/08\\\/womac-pain-chart.webp\",\"contentUrl\":\"https:\\\/\\\/hcp.cingal.com\\\/wp-content\\\/uploads\\\/sites\\\/2\\\/2026\\\/08\\\/womac-pain-chart.webp\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/hcp.cingal.com\\\/clinical-evidence\\\/trials-studies\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/hcp.cingal.com\\\/home\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Clinical Evidence\",\"item\":\"https:\\\/\\\/hcp.cingal.com\\\/clinical-evidence\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Clinical Trials &amp; 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