{"id":442,"date":"2026-04-20T20:40:35","date_gmt":"2026-04-20T19:40:35","guid":{"rendered":"https:\/\/hcp.cingal.com\/?page_id=442"},"modified":"2026-09-01T12:27:01","modified_gmt":"2026-09-01T11:27:01","slug":"about-cingal","status":"publish","type":"page","link":"https:\/\/hcp.cingal.com\/de\/about-cingal\/","title":{"rendered":"Cingal \u2013 \u00dcberblick"},"content":{"rendered":"\n
\n
\n \"Cingal
<\/div>\n <\/div>\n \n
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Cingal Overview<\/h1>\n\n

Cingal is a next-generation, non-opioid single-injection therapy for the symptomatic treatment of knee osteoarthritis (OA).<\/span>1<\/sup>\u00a0It combines hyaluronic acid (HA) viscosupplementation with a corticosteroid (triamcinolone hexacetonide) in one pre-filled syringe, delivering both rapid onset and sustained pain relief.2<\/sup>\u00a0Cingal is designed to work through both biological and mechanical mechanisms, reflecting the multiple factors involved in OA symptoms.<\/p>\n<\/div>\n\n

\n What is Cingal?<\/a>Comparison to Other Therapies<\/a><\/div>\n <\/div>\n\n <\/div>\n<\/section>\n\n\n\n
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Dual-action in a single injection<\/h2>\n\t\t\t\n\t\t\t\t\t\t\t

Cingal is administered via intra-articular injection during a routine office visit and is intended for patients with mild to moderate knee OA who require prompt symptom relief without repeated injections.<\/p>\n\t\t\t\t\t<\/div>\n\t\n\t\t\t\t\t\t\t\t

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Corticosteroid<\/p>\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t

Triamcinolone Hexacetonide (TH)<\/h3>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t
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Rapid anti-inflammatory relief<\/strong><\/p>\n

TH rapidly suppresses intra-articular inflammation, reducing pain within days of injection. Its low aqueous solubility and high receptor binding affinity support a sustained local effect of approximately 21 days.3<\/sup><\/p>\n

Onset: within days2<\/sup><\/p><\/blockquote>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

\n\n\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t

Viscosupplement<\/p>\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t

Hyaluronic Acid (HA)<\/h3>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t
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Sustained joint lubrication<\/strong><\/p>\n

Cross-linked, non-animal-sourced HA restores synovial fluid viscoelasticity, supporting lubrication, shock absorption, and longer-term symptom improvement. Bacterial fermentation source ensures no avian-derived components.<\/p>\n

Duration: up to 6 months2<\/sup><\/p><\/blockquote>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\n\t\n<\/section>\n\n\n\n

\"Banner<\/figure>\n\n\n<\/div><\/div><\/section>\n\n\n\n
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Real Life Advantages<\/h2>\n \n

Cingal\u2019s dual-component formulation addresses both the acute and chronic stages of knee OA, providing clinicians with a convenient single-injection treatment option.<\/p>\n<\/div>\n \n <\/div>\n \n

\n
\n \"icon-Dual-action <\/div>\n \n

Dual-action mechanism<\/h3>\n \n

Rapid anti-inflammatory effect from TH plus long-term joint lubrication and cushioning from cross-linked HA, both delivered in a single injection.<\/span>2<\/sup><\/p>\n<\/div>\n \n <\/div>\n

\n
\n \"icon-Clinically <\/div>\n \n

Clinically proven efficacy<\/h3>\n \n

Three Phase III clinical trials demonstrating sustained benefit through 6 months, including OMERACT-OARSI responder analysis.2,4,5<\/sup><\/p>\n<\/div>\n \n <\/div>\n

\n
\n \"icon-Non-opioid <\/div>\n \n

Non-opioid pain management<\/h3>\n \n

Aligned with contemporary OA and chronic pain pathways that prioritise non-opioid, intra-articular approaches for moderate-to-severe symptoms.<\/span><\/p>\n<\/div>\n \n <\/div>\n

\n
\n \"icon-Proven <\/div>\n \n

Proven clinical use in knee OA<\/h3>\n \n

Indicated for the relief of pain, stiffness, and functional limitation associated with knee osteoarthritis. Relevant across orthopaedic, rheumatology, pain, and MSK specialties.<\/span>1,2<\/sup><\/p>\n<\/div>\n \n <\/div>\n

\n
\n \"icon-Non-animal <\/div>\n \n

Non-animal HA source<\/h3>\n \n

Hyaluronic acid produced by bacterial fermentation, with no avian-derived components. Relevant for patients with known avian sensitivities.<\/span>1<\/sup><\/p>\n<\/div>\n \n <\/div>\n

\n
\n \"icon-High <\/div>\n \n

High HA concentration<\/h3>\n \n

22 mg\/mL cross-linked HA (high molecular weight within the biologically relevant range, cross-linked to extend intra-articular residence time).<\/span>1<\/sup><\/p>\n<\/div>\n \n <\/div>\n

\n
\n \"icon-Single-injection <\/div>\n \n

Single-injection convenience<\/h3>\n \n

One visit, one sterile pre-filled syringe, reducing procedural burden in high-throughput orthopaedic, rheumatology, and MSK clinics.6<\/sup><\/p>\n<\/div>\n \n <\/div>\n

\n
\n \"icon-Registered <\/div>\n \n

Registered in 45+ countries<\/h3>\n \n

Approved and in active clinical use in over 45 countries worldwide7<\/sup>, with an established post-market safety and repeat-injection record.8<\/sup><\/p>\n

\u00a0<\/p>\n<\/div>\n \n <\/div>\n \n \n

\n Discover the Science Behind Cingal<\/a> <\/div>\n <\/div>\n<\/section>\n\n\n\n
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Explore Cingal in Depth<\/h2>\n \n \n <\/div>\n \n
\n
\n \"icon-Single-injection <\/div>\n \n

Learn More About Cingal<\/h3>\n \n

Complete clinical product profile: formulation science, HA cross-linking, TH mechanism, chondroprotective data, and clinical profile at a glance.<\/p>\n<\/div>\n \n \n Learn More <\/a>\n <\/div>\n

\n
\n \"icon-Clinically <\/div>\n \n

Comparison to Other Therapies<\/h3>\n \n

Head-to-head overview: Cingal vs. corticosteroid-only, HA-only, and sequential injection approaches, including place-in-therapy pathway.<\/p>\n<\/div>\n \n \n Learn More <\/a>\n <\/div>\n \n \n <\/div>\n<\/section>\n\n\n\n

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Continue your clinical evaluation<\/h2>\n\n\n\n

Phase III evidence data, administration and patient selection criteria<\/p>\n\n\n\n

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Clinical Evidence<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div><\/section>\n\n\n\n\n
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\n\t\t\n\t\t\t\n\t\t\t\t\n\t\t\t\tReferences<\/span>\n\t\t\t<\/span>\n\t\t\t\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t<\/svg>\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t<\/svg>\n\t\t\t<\/span>\n\t\t<\/button>\n\t\t\n\t\t\t
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  1. Instructions for Use. Cingal. Anika Therapeutics. [Refer to current IFU for approved indications.]<\/li>\n
  2. Hangody L, et al. Intraarticular injection of a cross-linked sodium hyaluronate combined with triamcinolone hexacetonide (Cingal) to provide symptomatic relief of osteoarthritis of the knee: a randomized, double-blind, placebo-controlled multicenter clinical trial.\u00a0Cartilage.<\/em>\u00a02018;9(3):276\u2013283. doi: 10.1177\/1947603517703732.<\/li>\n
  3. Stephens M., et. al. Musculoskeletal Injections: A Review of the Evidence. Am Fam Physician. 2008 Oct 15;78(8):971-976<\/li>\n
  4. Data on file 16-02<\/li>\n
  5. Data on file 19-01<\/li>\n
  6. Belzile EL, Deakon RT, Vannabouathong C, Bhandari M, Lamontagne M, McCormack R. Cost-Utility of a Single-Injection Combined Corticosteroid-Hyaluronic Acid Formulation vs a 2-Injection Regimen of Sequential Corticosteroid and Hyaluronic Acid Injections. Clin Med Insights Arthritis Musculoskelet Disord. 2017 Jun 12<\/li>\n
  7. Anika Sales Data on File<\/li>\n
  8. Data on file 13-02<\/li>\n<\/ol>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-442","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nCingal Overview: HA + Corticosteroid for Knee OA<\/title>\n<meta name=\"description\" content=\"Cingal combines hyaluronic acid and triamcinolone hexacetonide in one injection, delivering rapid onset and sustained relief for knee osteoarthritis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hcp.cingal.com\/de\/about-cingal\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" 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